Publications
2024
E. A. Ding, T. J. Yokokura, R. Wang, and S. Kumar. Dissecting neurofilament tail sequence-phosphorylation-structure relationships with multicomponent reconstituted protein brushes (2024). Proceedings of the National Academy of Sciences (PNAS) (in press).
E. M. Carvalho, E. A. Ding, A. Saha, D. Cruz Garcia, A. Weldy, P. H. Zushin, A. Stahl, M. K. Aghi, and S. Kumar (2024). Viscoelastic high molecular-weight hyaluronic acid hydrogels support rapid glioblastoma cell invasion with leader-follower dynamics. Advanced Materials (in press).
J. Cha, E. A. Ding, E. M. Carvalho, A. Fowler, M. K. Aghi, and S. Kumar (2024). Collagen VI deposition primes the glioblastoma microenvironment for invasion through mechanostimulation of β-catenin signaling. PNAS Nexus 3: pgae355 (PDF).
E. Qiao*, J. Baek*, C. Fulmore, M. Song, T.-S. Kim, S. Kumar** and D. V. Schaffer** (2024). Spectrin mediates 3D-specific matrix stress-relaxation response in neural stem cell lineage commitment. Science Advances 10: eadk8232. [*equal contribution; **co-corresponding] (PDF)
K. Y. Amofa, K. M. Patterson, J. Ortiz, and S. Kumar (2024). Dissecting TGF-β-induced glioblastoma invasion with engineered hyaluronic acid hydrogels. APL Bioengineering
E. Qiao, C. A. Fullmore, D. V. Schaffer,* and S. Kumar* (2024). Substrate stress relaxation regulates neural stem cell fate commitment. Proceedings of the National Academy of Sciences (PNAS) 121 (28) e2317711121. [*co-corresponding] (PDF).
E. A. Ding and S. Kumar (2024). Neurofilament Biophysics: From structure to biomechanics. Molecular Biology of the Cell 35: re1 (PDF).
J. Baek, S. Kumar*, and D. V. Schaffer* (2024). Dynamic Light-Responsive RhoA Activity Regulates Mechanosensitive Stem Cell Fate Decision in 3D Matrices. Biomaterials Advances 160: 213836 (PDF).
J. H. Garcia, E. A. Akins, S. Jain, K. J. Wolf, J. Zhang, N. Choudhary, M. Lad, P. Shukla, S. Gill, W. Carson, L. Carette, A. Zheng, S. Kumar, and M. K. Aghi (2024). Multi-omic screening of invasive GBM cells in engineered biomaterials and patient biopsies reveals targetable transsulfuration pathway alterations. Journal of Clinical Investigation 134(3):e170397 (PDF)(Science Perspectives).
T. J. Yokokura, C. Duan, E. A. Ding, S. Kumar, and R. Wang (2024). The Effects of Ionic Strength on the Morphology, Scattering, and Mechanical Response of Neurofilament-derived Protein Brushes. Biomacromolecules 25(1):328-337 (PDF).
2023
C. D. Morley, E. A. Ding, E. M. Carvalho, and S. Kumar (2023). A Balance Between Inter- and Intra- Microgel Mechanics Governs Stem Cell Viability in Injectable Dynamic Granular Hydrogels. Advanced Materials 35: 2304212 (PDF).
R.G. Sampayo, M. Sakamoto, M. Wang, S. Kumar,* and D.V. Schaffer* (2023). Mechanosensitive Stem Cell Fate Choice is Instructed by Dynamic Fluctuations in Activation of Rho GTPases. Proceedings of the National Academy of Sciences (PNAS) 120: e2219854120 [*co-corresponding] (PDF).
E. M. Carvalho and S. Kumar (2023). Lose the stress: Viscoelastic materials for cell engineering. Acta Biomaterialia 163: 146-157 (PDF).
2022
C. S. Martins, C. Taveneau, G. Castro-Linares, M. Baibakov, N. Buzhinsky, M. Eroles, V. Milanovic, S. Omi, J.-P. Pedelacq, F. Iv, L. Bouillard, A. Llewellyn, M. Gomes, M. Belhabib, M. Kuzmic, P. Verdier-Pinard, S. Lee, A. Badache, S. Kumar, C. Chandre, S. Brasselet, F. Rico, O. Rossier, G. Koenderink, J. Wenger, S. Cabantous, and M. Mavrakis (2023). Human septins organize as octamer-based filaments and mediate actin-membrane anchoring in cells. Journal of Cell Biology 222(3), e202203016 (PDF) (JCB Spotlight).
J. Baek, S. Kumar, D. V. Schaffer and S. G. Im (2022). N-Cadherin adhesive ligation regulates mechanosensitive neural stem cell lineage commitment in 3D matrices. Biomaterials Science 10: 6768-6777 (PDF).
S. B. Kokate, K. Ciuba, V. D. Tran, R. Kumari, S. Tojkander, U. Engel, K. Kogan, S. Kumar, and P. Lappalainen (2022). Caldesmon controls stress fiber force-balance through dynamic cross-linking of myosin II and actin-tropomyosin filaments. Nature Communications 13: 6032 (PDF).
J. Baek, P. A. Lopez, S. Lee, T.-S. Kim, S. Kumar,* and D. V. Schaffer* (2022). Egr1 is a 3D matrix-specific mediator of mechanosensitive stem cell lineage commitment. Science Advances 8: eabm4646 [*co-corresponding] (PDF).
G. F. Beeghly, K. Y. Amofa, C. Fischbach and S. Kumar (2022). Regulation of Tumor Invasion by the Physical Microenvironment: Lessons from Breast and Brain Cancer. Annual Review of Biomedical Engineering 24:1, 29-59 (PDF).
2021
R. Lei, E. A. Akins, K. C. Y. Wong, N. A. Repina, K. J. Wolf, G. E. Dempsey, D. V. Schaffer, A. Stahl, and S. Kumar (2021). Multiwell Combinatorial Hydrogel Array for High-Throughput Analysis of Cell–ECM Interactions. ACS Biomaterials Science and Engineering 7: 2453-2465 (PDF).
V. Tran and S. Kumar (2021). Transduction of cell and matrix geometric cues by the actin cytoskeleton. Current Opinion in Cell Biology 68:64–71 (PDF).
2020
E. A. Akins, M. K. Aghi, and S. Kumar (2020). Incorporating tumor-associated macrophages into engineered models of glioma. iScience 23: 101770 (PDF).
R. Lei and S. Kumar (2020). Getting the big picture of cell-matrix interactions: High-throughput biomaterial platforms and systems-level measurements. C
S. Lee and S. Kumar (2020). Cofilin is required for polarization of tension in stress fiber networks during migration. Journal of Cell Science (DOI 10.1242/jcs.
K. J. Wolf, P. Shukla, K. Springer, S. Lee, J. D. Coombes, C. J. Choy, S. J. Kenny, K. Xu, and S. Kumar (2020). A mode of cell adhesion and migration facilitated by CD44-dependent microtentacles. 117: 11432-11443
N. F. Huang, O. Chaudhuri, P. Cahan, A. Wang, A. J. Engler, Y. Wang, S. Kumar, and S. Li (2020). Multi-scale cellular engineering: From molecules to organ-on-a-chip. APL Bioengineering DOI 10.1063/1.5129788 (PDF).
A. Chandra, A. Jahangiri, W. Chen, A. T. Nguyen, G. Yagnik, M. P. Pereira, S. Jain, J. H. Garcia, S. S. Shah, H. Wadhwa, R. S. Joshi, J. Weiss, K. J. Wolf, J.-M. G. Lin, S. Mueller, J. W. Rick, A. A. Diaz, L. A. Gilbert, S. Kumar, and M. K. Aghi (2020). Clonal ZEB1-
C. Rianna, M. Radmacher, and S. Kumar (2020). Direct evidence that tumor cells soften when navigating confined spaces. Molecular Biology of the Cell 31: 1726-1734 (PDF).
P.H. Kang, D.V. Schaffer and S. Kumar (2020). Angiomotin links ROCK and YAP signaling in mechanosensitive differentiation of neural stem cells. Molecular Biology of the Cell 31: 386-396 (PDF).
B.T. Larson, T. Ruiz-Herrero, S. Lee, S. Kumar, L. Mahadevan, and N. King (2020). Biophysical principles of choanoflagellate self-organization.
J. Chen, B. Ananthanarayanan, K.S. Springer, K.J. Wolf, S.M. Sheyman, V.D. Tran and S. Kumar (2020). Suppression of LIM Kinase 1 and LIM Kinase 2 Limits Glioblastoma Invasion. Cancer Research (PDF).
2019
K. J. Wolf, J. Chen, J. D. Coombes, M. K. Aghi and S. Kumar (2019). Dissecting and rebuilding the glioblastoma microenvironment with engineered materials. Nature Reviews Materials 4: 651-668 (PDF).
E. L. Qiao, S. Kumar and D. V. Schaffer (2019). Mastering their own fates through the matrix. Nature Materials 18: 779-780 (PDF).
J. H. Hughes, J. M. Ewy, J. Chen, S. Y. Wong, K. M. Tharp, A. Stahl and S. Kumar (2019) Transcriptomic analysis reveals that BMP4 sensitizes glioblastoma tumor-initiating cells to mechanical cues. Matrix Biology 85-86: 112-127 (PDF).
E. Kassianidou, D. Probst, J. Jager, S. Lee, A.-L. Roguet, U.S. Schwarz, S. Kumar (2019). Extracellular Matrix Geometry and Initial Adhesive Position Determine Stress Fiber Network Organization during Cell Spreading. Cell Reports 27: 1897–1909 (PDF).
S. H. Klass, M. J. Smith, T. A. Fiala, J. P. Lee, A. O. Omole, B. G. Han, K. H. Downing, S. Kumar, and M. B. Francis (2019). Self-Assembling Micelles Based on an Intrinsically Disordered Protein Domain. Journal of the American Chemical Society 141: 4291-4299 (PDF).
K. J. Wolf and S. Kumar (2019). Hyaluronic Acid: Incorporating the Bio into the Material. ACS Biomaterials Science and Engineering 5: 3753-3765 (PDF).
2018
M. M. Adil, A.T. Rao, G.N. Ramadoss, N.E. Chernavsky, R.U. Kulkarni, E.W. Miller, S. Kumar, and D.V. Schaffer (2018). Dopaminergic neurons transplanted using cell-instructive biomaterials alleviate Parkinsonism in rodents. Advanced Functional Materials 28: 1804144 (PDF).
S. Lee, E. Kassianidou, and S. Kumar (2018). Actin myosin stress fiber subtypes have unique viscoelastic properties and roles in tension generation. Molecular Biology of the Cell 29: 1992-2004 (PDF).
K. J. Wolf, S. Lee, and S. Kumar (2018). A 3D topographical model of parenchymal infiltration and perivascular invasion in glioblastoma. APL Bioengineering 2: 031903 (PDF).
R. Lei, J. P. Lee, M. J. Francis, and S. Kumar (2018). Structural regulation of a neurofilament-inspired intrins
K.M. Tharp, M.S. Kang, G.E. Thimblin, J. Dempersmier, G.E. Dempsey, P.J.H. Zushin, J. Benavides, C. Choi, C.X. Lei, A.K. Jha, S. Kaijmura, K.E. Healy, H.S. Sul, K. Saijo, S. Kumar, A. Stahl (2018). Actomyosin-mediated tension orchestrates uncoupled respiration in adipose tissues. Cell Metabolism 27: 602-615 (PDF).
J.-M. Lin, C.-C. Kang, Y. Zhou, H. Huang, A. H. Herr, S. Kumar (2018). Linking invasive motility to protein expression in single tumor cells. Lab on a Chip 18:371-384. (PDF).
2017
P. Kang, S. Kumar,* and D.V. Schaffer* (2017). Making way for neural stemness. Nature Materials 16:1174-1176 [*co-
E. Kassianidou, J. H. Hughes, and S. Kumar (2017). Activation of ROCK and MLCK tunes regional stress fiber formation and mechanics via preferential myosin light chain phosphorylation. Molecular Biology of the Cell 28: 3832-3843 (PDF).
P. Kang, S. Kumar,* and D. V. Schaffer* (2017). Novel biomaterials to study neural stem cell mechanobiology and improve cell-replacement therapies. Current Opinion in Biomedical Engineering 4:13-20 [*co-corresponding] (PDF).
A. D. Rape and S. Kumar (2017). Engineering advanced models of the glioblastoma microenvironment using biomaterials. Book chapter for Extracellular Matrix in Tumor Biology, Springer (R. A. Brekken and D. Stuck, Eds.) (PDF).
S. Maity, C. M. Sadlowski, J. M. Lin, C. Chen, L. Peng, E. Lee, G. Vegesna, C. Lee, Se-Hwa Kim, D. Mochly-Rosen, S. Kumar and N. Murthy (2017). Thiophene bridged aldehydes (TBAs) image ALDH activity in cells via modulation of intromolecular charge transfer. Chemical Science 8(10):7143-7151 (PDF).
A. E. Shyer, A. R. Rodrigues, G. G. Schroeder, E. Kassianidou, S. Kumar, and R. M. Harland (2017). Emergent cellular self-organization and mechanosensation initiate follicle pattern in the avian skin. Science 357: 811-815. (PDF) (Science Perspectives).
M. M. Adil,* T. Vazin,* B. Ananthanarayanan,* G. M. C. Rodrigues, A. T. Rao, R. U. Kulkarni, E. W. Miller, S. Kumar, and D. V. Schaffer (2017). Engineered hydrogels increase the post-transplantation survival of encapsulated hESC-derived midbrain dopaminergic neurons. Biomaterials 136: 1-11 (PDF) [*equal contribution].
J. Chen and S. Kumar (2017). Biophysical regulation of cancer stem/initiating cells: implications for disease mechanisms and translation. Current Opinion in Biomedical Engineering 1:87-95 (PDF).
S. Rammensee,* M. S. Kang,* K. Georgiou, S. Kumar,** and D. V. Schaffer** (2017). Dynamics of mechanosensitive neural stem cell differentiation. Stem Cells 35: 497-506 (PDF) [*equal contribution; **co-corresponding].
E. Kassianidou, C. A. Brand, U. S. Schwarz, and S. Kumar (2017). Geometry and network connectivity govern stress fiber mechanics. Proceedings of the National Academy of Sciences (PNAS) 114: 2622-2627 (PDF).
2016
L. Guillou,* J. B. Dahl,* J. M. Lin,* A. I. Barakat, J. Husson, S. J. Muller, and S. Kumar (2016). Measuring cell viscoelastic properties using a microfluidic extensional flow device. Biophysical Journal 111: 2039-2050 (PDF) [*equal contribution].
S. Lee and S. Kumar (2016). Actomyosin stress fiber mechanosensing in 2D and 3D. F1000 Faculty Reviews 5: 2261 (PDF).
J. P. Lee, E. Kassianidou, J. I. MacDonald, M. B. Francis, and S. Kumar (2016). N-terminal specific conjugation of extracellular matrix proteins to 2-pyridinecarboxaldehyde functionalized polyacrylamide hydrogels. Biomaterials 102: 268-276 (PDF).
M. Bhagawati, M. G. Rubashkin, J. P. Lee, B. Ananthanarayanan, V. M. Weaver, and S. Kumar (2016). Site-specific modulation of charge controls the structure and stimulus-responsiveness of intrinsically disordered peptide brushes. Langmuir 32: 5990-5996 (PDF).
T. Luque*, M. S. Kang*, D. V. Schaffer, and S. Kumar (2016). Microelastic mapping of the rat dentate gyrus. Royal Society Open Science 3: 150702 (PDF) [*equal contribution].
J. B. Dahl, V. Narasimhan, B. Gouvela, S. Kumar, E. S. G. Shaqfeh, and S. J. Muller (2016). Experimental observation of the asymmetric instability of intermediate-reduced-volume vesicles in extensional flow. Soft Matter 12: 3787-3796 (PDF).
J. H. Hughes and S. Kumar (2016). Synthetic mechanobiology: Engineering cellular force generation and signaling. Current Opinion in Biotechnology 40: 82-89 (PDF).
R. A. Gould, H. C. Yalcin, J. L. MacKay, K. Sauls, R. Norris, S. Kumar, and J. T. Butcher (2016). Cyclic mechanical loading is essential for Rac-1-mediated elongation and remodeling of the embryonic mitral valve. Current Biology 26: 27-37 (PDF).
2015
A. D. Rape, M. Zibinsky, N. Murthy, and S. Kumar (2015). A synthetic hydrogel for the high-throughput study of cell–ECM interactions. Nature Communications 6: 8129 (PDF)
J. Santiago-Ortiz, D. S. Ojala, O. Westesson, J. R. Weinstein, S. Y. Wong, S. Kumar, I. Holmes, and D. V. Schaffer (2015). AAV ancestral reconstruction library enables selection of broadly infectious viral variants. Gene Therapy 22: 934-946 (PDF).
A. D. Rape and S. Kumar (2015). Engineering strategies to recapitulate the tumor microenvironment. Book chapter for Cells, Forces, and the Microenvironment, CRC Press-Taylor and Francis Group, LLC (C. M. Cuerrier and A. E. Pelling, eds.) (PDF).
C.-W. Chang and S. Kumar (2015). Differential contributions of nonmuscle myosin II isoforms and functional domains to stress fiber mechanics. Scientific Reports 5: 13736 (PDF).
E. Kassianidou and S. Kumar (2015). A biomechanical perspective on stress fiber structure and function. BBA Molecular Cell Research 1853: 3065-3074 (PDF).
J. B. Dahl*, J.-M. Lin*, S. J. Muller, and S. Kumar (2015). Microfluidic strategies for understanding the mechanics of cells and cell-mimetic systems. Annual Review of Chemical and Biomolecular Engineering 6: 293-317 (PDF) [*equal contribution].
S. Y. Wong, T. A. Ulrich, L. P. Deleyrolle, J. L. MacKay, J.-M. Lin, R. T. Martuscello, M. A. Jundi, B. A. Reynolds, and S. Kumar (2015). Constitutive activation of myosin-dependent contractility sensitizes glioma tumor-initiating cells to mechanical inputs and reduces tumor invasion. Cancer Research 75: 1113-1122 (PDF).
2014
M. Bhagawati and S. Kumar (2014). Biofunctionalization of hydrogels for engineering the cellular microenvironment. Book chapter for Micro- and Nanoengineering the Cell Surface, Elsevier (J .M. Karp and W. Zhao, eds.) (PDF).
S. Y. Wong and S. Kumar (2014). Matrix regulation of tumor-initiating cells. Book chapter for Mechanotransduction, Elsevier. Indexed as Progress in Molecular Biology and Translational Science 126: 243-256 (PDF).
N. Srinivasan, M. Bhagawati, B. Ananthanarayanan, and S. Kumar (2014). Stimuli-sensitive intrinsically disordered protein brushes. Nature Communications 5: 5145 DOI 10.1038/ncomms6145 (PDF).
Y. Qiu, A. C. Brown, D. R. Myers, Y. Sakurai, R. G. Mannino, R. Tran, B. Ahn, E. T. Hardy, M. F. Kee, S. Kumar, G. Bao, T. H. Barker, and W. A. Lam (2014). Platelet mechanosensing of substrate stiffness during clot formation mediates adhesion, spreading, and activation. Proceedings of the National Academy of Sciences (PNAS) 111: 14430 – 14435 (PDF).
S. Kumar (2014). Cellular mechanotransduction: stiffness does matter. Nature Materials 13: 918-920 (PDF).
C. C. Kang, J. M. Lin, Z. Xu, S. Kumar, and A. E. Herr (2014). Single-cell western blotting after whole-cell imaging to assess cancer chemotherapeutic response. Analytical Chemistry 86: 10429-10436 (PDF)
A. D. Rape, B. Ananthanarayanan, and S. Kumar (2014). Engineering strategies to mimic the glioblastoma microenvironment. Advanced Drug Delivery Reviews 79-80: 172-183 (PDF).
J. L. MacKay and S. Kumar (2014). Simultaneous and independent tuning of RhoA and Rac1 activity with orthogonally inducible promoters. Integrative Biology 6: 885-894 (PDF).
A. D. Rape and S. Kumar (2014). A composite hydrogel platform for the dissection of tumor cell migration at tissue interfaces. Biomaterials 35: 8846-8853 (PDF).
Y. Kim and S. Kumar (2014). CD44-mediated adhesion to hyaluronic acid contributes to mechanosensing and invasive motility. Molecular Cancer Research 12: 1416-1429 (PDF). (MCR Highlights).
V. Umesh, A. Rape, T. A. Ulrich, and S. Kumar (2014). Microenvironmental stiffness enhances glioma cell proliferation by stimulating epidermal growth factor receptor signaling. PLoS ONE 9: E101771 (PDF).
F. A. Pelissier, J. C. Garbe, B. Ananthanarayanan, M. Miyano, C. Lin, T. Jokela, S. Kumar, M. R. Stampfer, J. B. Lorens, and M. A. LaBarge (2014). Age-related dysfunction in mechano-transduction impairs differentiation of human mammary epithelial progenitors. Cell Reports 7: 1926-1939 (PDF).
J. L. MacKay, A. Sood, and S. Kumar (2014). Three-dimensional patterning of multiple cell populations through orthogonal genetic control of cell motility. Soft Matter 10: 2372-2380 (PDF).
K. Kurpinski, T. Johnson, S. Kumar, T. Desai, and S. Li (2014). Mastering translational medicine: Interdisciplinary education for a new generation. Science Translational Medicine 6: 218fs2 (PDF).
2013
Y. Kim and S. Kumar (2013). The role of hyaluronic acid and its receptors in the growth and invasion of brain tumors. Book chapter for Tumors of the Central Nervous System, Springer Netherlands (PDF).
A. P. Acharya, P. M. Nafisi, A. Gardner, J. L. MacKay, K. Kundu, S. Kumar, and N. Murthy (2013). A fluorescent peroxidase probe increases the sensitivity of commercial ELISAs by two orders of magnitude. Chemical Communications 49: 10379-10381 (PDF).
A. Pathak and S. Kumar (2013). Transforming potential and matrix stiffness co-regulate confinement sensitivity of tumor cell migration. Integrative Biology 5: 1067-1075 (PDF).
A. J. Keung, M. Dong, D. V. Schaffer, and S. Kumar (2013). Pan-neuronal maturation but not neuronal subtype differentiation of adult neural stem cells is mechanosensitive. Scientific Reports 3: 1817 (PDF).
C.-W. Chang and S. Kumar (2013). Vinculin tension distributions of individual stress fibers within cell-matrix adhesions. Journal of Cell Science 126: 3021 – 3030 (PDF) (JCB In This Issue).
S. Kumar (2013). Microtubule assembly: Switched on with magnets. Nature Nanotechnology 8: 162-163 (PDF).
J. L. MacKay and S. Kumar (2013). Measuring the elastic properties of living cells with atomic force microscopy indentation. Methods in Molecular Biology 931: 313-329 (PDF).
2012
S. Kumar (2012). Cell-extracellular matrix mechanobiology in cancer. Comprehensive Biophysics 7: 142-167 (PDF).
G. Brown et al. (2012). Cellular and molecular bioengineering: A tipping point. Cellular and Molecular Bioengineering 5: 239-253 (PDF)
A. J. Keung, P. Asuri, S. Kumar*, and D. V. Schaffer* (2012). Soft microenvironments promote the early neurogenic differentiation but not self-renewal of human pluripotent stem cells. Integrative Biology 4: 1049 – 1058 (PDF) [*co-corresponding].
A. Pathak and S. Kumar (2012). Independent regulation of tumor cell migration by matrix stiffness and confinement. Proceedings of the National Academy of Sciences (PNAS) 109 (26): 10334-10339 (PDF).
S. Sen, W. P. Ng, and S. Kumar (2012). Contributions of talin-1 to glioma cell-matrix tensional homeostasis. Journal of the Royal Society Interface 9: 1311-1317 (PDF).
J. L. MacKay, A. J. Keung, and S. Kumar (2012). A genetic strategy for the dynamic and graded control of cell mechanics, motility, and matrix remodeling. Biophysical Journal 102: 434-442 (PDF).
N. Srinivasan and S. Kumar (2012). Ordered and disordered proteins as nanomaterial building blocks. WIREs Nanomedicine and Nanobiotechnology 4:204–218 (PDF).
2011
A. J. Keung*, E. M. de Juan-Pardo*, D. V. Schaffer, and S. Kumar (2011). Rho GTPases mediate the mechanosensitive lineage commitment of neural stem cells. Stem Cells 29: 1886-1897 (PDF) [*equal contribution].
A. A. Patel, T. A. Desai, and S. Kumar (2011). Microtopographical assembly of cardiomyocytes. Integrative Biology 3: 1011-1019 (PDF).
B. Ananthanarayanan, Y. Kim, and S. Kumar (2011). Elucidating the mechanobiology of malignant brain tumors using a brain matrix-mimetic hyaluronic acid hydrogel platform. Biomaterials 32: 7913-7923 (PDF).
T. A. Ulrich, T. G. Lee, H. K, Shon, D. W. Moon, and S. Kumar (2011). Microscale mechanisms of agarose-induced disruption of collagen remodeling. Biomaterials 32: 5633-5642 (PDF).
A. Pathak and S. Kumar (2011). Biophysical regulation of tumor cell invasion: Moving beyond matrix stiffness. Integrative Biology 3: 267-278 (PDF).
A. Pathak and S. Kumar (2011). From molecular signal activation to locomotion: An integrated, multiscale analysis of cell motility on defined matrices. PLoS ONE 6: E18423 (PDF).
T. A. Ulrich and S. Kumar (2011). Mechanobiology in health and disease in the central nervous system. Book chapter for Mechanobiology Handbook, CRC Press-Taylor and Francis Group, LLC (PDF).
S. Sen, W. P. Ng, and S. Kumar (2011). Contractility dominates adhesive ligand density in regulating cellular de-adhesion and retraction kinetics. Annals of Biomedical Engineering 39: 1163-1173 (PDF).
J. Lee, B. H. Chu, S. Sen, A. Gupte, T. J. Chancellor, C.-Y. Chang, F. Ren, S. Kumar, and T. P. Lele (2011). Modulating malignant epithelial tumor cell adhesion, migration and mechanics with nanorod surfaces. Biomedical Microdevices 13: 89-95 (PDF).
2010
K. Tanner, A. Boudreau, M. J. Bissell, and S. Kumar (2010). Dissecting regional variations in stress fiber mechanics in living cells with laser nanosurgery. Biophysical Journal 99: 2775-2783 (PDF).
A. J. Keung, S. Kumar, and D. V. Schaffer (2010). Presentation counts: Microenvironmental regulation of stem cells by biophysical and material cues. Annual Review of Cell and Developmental Biology 26: 533-556 (PDF).
B. Ananthanarayanan and S. Kumar (2010). Cell mechanobiology in regenerative medicine: Lessons from cancer. Book chapter for the CRC Biomedical Engineering Handbook, CRC Press-Taylor and Francis Group, LLC (PDF).
A. J. Keung, K. E. Healy, S. Kumar, and D. V. Schaffer (2010). Biophysics and dynamics of natural and engineered stem cell microenvironments. Wiley Interdisciplinary Reviews (WIREs): Systems Biology and Medicine 2: 49-64 (PDF).
W. A. Lam, L. Cao, V. Umesh, A. J. Keung, S. Sen, and S. Kumar (2010). Extracellular matrix rigidity modulates neuroblastoma cell differentiation and N-Myc expression. Molecular Cancer 9: 35 (PDF).
A. Patel, R. G. Thakar, M. Chown, P. Ayala, T. A. Desai, and S. Kumar (2010). Biophysical Mechanisms of Single-Cell Interactions with Microtopographical Cues. Biomedical Microdevices 12: 287-296 (PDF).
T. A. Ulrich, A. Jain, K. Tanner, J. L. MacKay, S. Kumar (2010). Probing cellular mechanobiology in three-dimensional culture with collagen-agarose matrices. Biomaterials 31: 1875-1884 (PDF).
S. Sen and S. Kumar (2010). Combining mechanical and optical approaches to dissect cellular mechanobiology. Journal of Biomechanics 43: 45-54 (PDF).
2009
S. Sen, M. Dong, and S. Kumar (2009). Isoform-specific contributions of α-actinin to glioma cell mechanobiology. PLoS ONE 4: E8427 (PDF).
S. Kumar, P. Parot, J. L. Pellequer (2009). Second international AFM Biomed conference on AFM in the life sciences and medicine, 16-18 October 2008, Monterey, CA, USA [editorial]. Journal of Molecular Recognition 22: 345-346. (PDF)
D. J. D’Sa, E. M. de Juan Pardo, R. de las Rivas Astiz, S. Sen, and S. Kumar (2009). High-throughput indentational elasticity measurements of hydrogel extracellular matrix substrates. Applied Physics Letters 95:63701 1-3 (PDF).
S. Sen and S. Kumar (2009). Cell-matrix de-adhesion dynamics reflect contractile mechanics. Cellular and Molecular Bioengineering 2: 218-230. (PDF).
T. A. Ulrich, E. M. de Juan Pardo, and S. Kumar (2009). The mechanical rigidity of the extracellular matrix regulates the structure, motility, and proliferation of glioma cells. Cancer Research 69: 4167-4174. (PDF).
S. Kumar and V. M. Weaver (2009). Mechanics, malignancy, and metastasis: The force journey of a tumor cell. Cancer and Metastasis Reviews 28:113-127. (PDF)
2008
Luo, Y., Xu, X., Lele, T., Kumar, S., and Ingber, D.E. (2008). A multimodular tensegrity model of an actin stress fiber. Journal of Biomechanics 41: 2379-2387. (PDF)
R. G. Thakar, M. G. Chown, A. Patel, L. Peng, S. Kumar, and T. A . Desai (2008). Contractility-dependent modulation of cell proliferation and adhesion by microscale topographical cues. Small 4: 1416-1424. (PDF)
R. J. Mannix*, S. Kumar*, F. Cassiola, M. Montoya-Zavala, E. Feinstein, M. Prentiss, and D. E. Ingber (2008). Nanomagnetic actuation of receptor-mediated signal transduction. Nature Nanotechnology 3: 36-40 [*equal contribution]. (PDF) (Nat Nano News and Views).
2007
S. Kumar and P. R. Leduc (2007). Dissecting the molecular basis of the mechanics of living cells. Experimental Mechanics 49: 11-23 [published online August 10, 2007; in print February 2009]. (PDF).
M. Chown and S. Kumar (2007). Imaging and manipulating the structural machinery of living cells on the micro- and nanoscale. International Journal of Nanomedicine 2: 333-344 (PDF) .
T. P. Lele, J. Sero, B. Matthews, S. Kumar, N. Xia, M. Montoya-Zavala, T. Polte, D. R. Overby, N. Wang, and D. E. Ingber (2007). Tools to study cell mechanics and mechanotransduction. In Cell Mechanics (Academic Press, Y.-L. Wang and D. E. Discher, Eds.) Methods in Cell Biology 83: 435-464. (PDF)
T. P. Lele and S. Kumar (2007). Brushes, cables, and anchors: Recent insights into multiscale assembly and mechanics of cellular structural networks. Cell Biochemistry and Biophysics 47: 348-360 (PDF).
2006
C. P. Brangwynne, F. C. MacKintosh, S. Kumar, N. A. Geisse, J. Talbot, L. Mahadevan, K. K. Parker, D. E. Ingber, and D. A. Weitz (2006). Microtubules can bear enhanced compressive loads in living cells because of lateral reinforcement. Journal of Cell Biology 173: 733-741. (PDF) (JCB In This Issue)
S. Kumar, I.Z. Maxwell, A. Heisterkamp, T.R. Polte, T.P. Lele, M. Salanga, E. Mazur, and D.E. Ingber (2006). Viscoelastic retraction of single living stress fibers and its impact on cell shape, cytoskeletal organization, and extracellular matrix mechanics. Biophysical Journal 90: 3762-3773. (PDF)
T. P. Lele, J. Pendse, S. Kumar, M. Salanga, J. Karavitis, and D. E. Ingber (2006). Mechanical forces alter zyxin unbinding kinetics within focal adhesions of living cells. Journal of Cellular Physiology 207: 187-194. (PDF)
2005
A. Heisterkamp, I. Z. Maxwell, E. Mazur, J. M. Underwood, J. A. Nickerson, S. Kumar, and D. E. Ingber (2005). Pulse energy dependence of subcellular ablation by femtosecond laser pulses. Optics Express 13: 3690-3696. (PDF)
2004 and earlier
S. Kumar and J. H. Hoh (2004). Modulation of repulsive forces between neurofilaments by sidearm phosphorylation. Biochemical and Biophysical Research Communications 324: 489-496. (PDF)
R. Mukhopadhyay, S. Kumar, and J. H. Hoh (2004). Molecular mechanisms for organizing the neuronal cytoskeleton. BioEssays 26: 1017-1025. (PDF)
S. Kumar, X. Yin, B. D. Trapp, M. E. Paulaitis, and J. H. Hoh (2002). Role of long-range repulsive forces in organizing axonal neurofilament distributions: Evidence from mice deficient in myelin-associated glycoprotein. Journal of Neuroscience Research 68: 681-690. (PDF)
J. Schneider, P. Berndt, K. Haverstick, S. Kumar, S. Chiruvolu, and M. Tirrell (2002). Surface force measurements of electrostatic and hydrogen-bonding interactions between bilayers of glycine amphiphiles. Langmuir 18: 3923-3931. (PDF)
S. Kumar, X. Yin, B. D. Trapp, J. H. Hoh, and M. E. Paulaitis (2002). Relating interactions between neurofilaments to the structure of axonal neurofilament distributions through polymer brush models. Biophysical Journal 82: 2360-2372. (PDF)
S. Kumar and J. H. Hoh (2001). Probing the machinery of intracellular trafficking with the atomic force microscope. Traffic 2: 746-756. (PDF)
S. Kumar and J. H. Hoh (2000). Direct visualization of vesicle-bilayer complexes by atomic force microscopy. Langmuir 16: 9936-9940. (PDF)
J. Schneider, P. Berndt, K. Haverstick, S. Kumar, S. Chiruvolu, and M. Tirrell (1998). Force and adhesion measurements between hydrogen-bonded layers of glycine-functionalized amphiphiles. Journal of the American Chemical Society 120: 3508-3509. (PDF)